The legalization of medical hemp has become a hot topic of discussion in many countries around the world. Hemp has historically been a crop with high economic output and fiber as a rope or weaving cloth. Seeds can also use to squeeze oil. CBD Oil Side Effects And has a wide range of medical value. And since the main components of Cannabidiol (Cannabidiol/CBD) and tetrahydrocannabinol (THC) w discover. A variety of medical uses have slowly emerged. What are the effects of CBD in empirical medicine? Are there any side effects or contraindications? See the text analysis for details.
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What is CBD?
CBD is the abbreviation of Cannabidiol (Cannabidiol). It is one of the nearly 100 active ingredients in the cannabis plant. Unlike the most famous tetrahydrocannabinol (THC), it does not produce euphoria and does not cause dependence. Or abuse (common commercial sales forms include gel, gum, CBD oil, powder, extract, etc.)
Due to its potential multiple therapeutic properties and good safety and tolerance, CBD is currently one of the most studied cannabinoids (cannabinoid), which has anti-inflammatory, anti-spasm, antioxidant, antiemetic, anti-anxiety, and Potential anti- benefits such as psychiatry, and have therapeutic effects on some refractory diseases (such as intractable epilepsy, Parkinson’s disease, anxiety, etc.), so it has gradually attracted attention.
CBD can interact positively with the endocannabinoid system in the human body. The endocannabinoid system is an important physiological system that can affect the human body’s various functions, pure CBD oil including brain plasticity, motor control, memory, and cognition. , Stress, emotional response, inflammation, appetite regulation, pain, learning, and memory
＊Tetrahydrocannabinol (THC for short) is a cannabis-like substance in cannabis, which has long been considered the principal psychoactive ingredient, that is, a substance that makes people hallucinogenic and addictive
What are the observed effects (benefits) of CBD/ cannabidiol?
- CBD benefits Delaware syndrome
Dravet Syndrome, also Papular as severe infantile myoclonic epilepsy of infancy, is a rare early-onset hereditary epilepsy syndrome, initially discovered by Charlotte Dravet in 1978 and 1989, Delaware syndrome.
It characterizes by the initial appearance of febrile or afebrile seizures in typically developed infants, which usually develop into status epilepticus, followed by convulsive seizures and complex partial seizures. In adulthood, it manifested as persistent motor and cognitive dysfunction.
A systematic literature review and meta-analysis (Meta-Analysis, including three randomized placebo-controlled trials, with a total of 359 Delaware syndrome participants) pointed out that CBD adjuvant therapy (Epidiolex, daily oral doses of 10 and 20 (Mg/kg) can reduce the frequency of convulsive seizures (convulsive seizures). Still, mild to moderate adverse events have also been observed.
The clinical definition of convulsive seizures is a rhythmic seizure that lasts less than 5 minutes. It can be local (affecting a limb or side of the body or face) or whole body (affecting the entire body).
Conclusion: For patients with Delaware syndrome, the use of CBD oil (cannabidiol) adjuvant therapy may reduce convulsive seizures, but limited by the small number of samples, more studies are needed to confirm its clinical benefits
CBD Benefits Regal Syndrome: CBD Oil Side Effects
Lennox-Gastaut syndrome is a severe epileptic and developmental encephalopathy, usually at the age of 7. The peak age of onset is 3 to 5 years. The incidence rate is about 2 cases per 100,000 people.
Atonic Epilepsy (drop seizures) is a characteristic of this disease. It is a type of spasm (involving the entire body, torso, or head) that suddenly causes the muscles to lose strength. CBD Oil Side Effects The patient usually stays awake and may cause falls, injuries, or falls. Sitting on a chair, or hitting the surface of the head, usually leads to severe injuries. Cognitive and intellectual impairments may accompany patients.
A systematic literature review and meta-analysis (Meta-Analysis, including two randomized placebo-controlled trials with a total of 396 Regale syndrome participants) pointed out that CBD adjuvant therapy (daily doses of 10 to 20 mg/kg) can reduce the frequency of seizures in atonic and non-atonic epilepsy. Also, mild to moderate adverse events have been observed: lethargy, decreased appetite, diarrhea, and increased serum transaminases.
Conclusion: For patients with Regal syndrome, the use of CBD adjuvant therapy may reduce seizures but is limited by the small number of samples. More studies are still needed to confirm its clinical benefits and safety.
CBD is beneficial for schizophrenia: CBD Oil Side Effects
Schizophrenia, also known as schizophrenia, is a highly heterogeneous mental illness that profoundly impacts patients. It usually occurs in early adulthood or late adolescence (affects about 0.3 to 0.7% of adults). Symptoms divide into three dimensions: positive symptoms (such as delusions, hallucinations), negative symptoms (such as emotional retardation, anhedonia), and cognitive symptoms ( Such as attention, memory, executive function).
The current pharmacological treatment is mainly based on dopamine blockade, and its effect is limited to positive symptoms. Besides, two-thirds of patients have adverse reactions to dopaminergic therapy. Therefore, there is an urgent need for alternative and more effective drug interventions to reduce the burden.
A systematic literature review and meta-analysis (including three randomized controlled trials) pointed out that CBD oil and amisulpride (amisulpride) were compared as a single treatment in a study. Still, the two were in There is no statistical difference in overall efficacy, and there is no data on cognition.
Two other studies evaluated the comparative effects of CBD oil as an additional treatment and placebo, CBD Oil Side Effects, and found no significant difference between the two in terms of overall efficacy and cognition.
Conclusion: Up to now, the efficacy and safety evidence of CBD oil for patients with schizophrenia is not yet sufficient, and more studies are needed for further confirmation
CBD benefits Parkinson’s disease: CBD Oil Side Effects
Parkinson’s Disease a disease caused by abnormalities in the basal ganglia in the extrapyramidal system. It has a prevalence rate of 2% over the age of 60. And the ratio of males to females is about 3:2. The percentage of patients will increase by six times. Incidence of dementia
Parkinson’s disease mainly characterizes by loss of dopaminergic function and decreased motor function (including resting tremor, slow movement, muscle stiffness). The etiological factors are related to exposure to pesticides and other toxic substances, family history, and ovariectomy, but aging is The most critical factor
A double-blind controlled study (participating 21 Parkinson’s disease patients without dementia or other mental conditions) pointed out that compared with placebo, CBD oil review the use of cannabidiol (CBD) has the effect of improving quality of life measures (but action Symptoms and neuroprotective benefits are not significantly different).
Conclusion: For patients with Parkinson’s disease who do not have psychiatric symptoms, cannabidiol (CBD) may improve their quality of life, but it has no significant effect on motor function
CBD beneficial to cardiovascular function
Cardiovascular disease is the most burdensome disease in the current medical system. And about 90% of common myocardial infarction related. To the attributable risk of the population. CBD Oil Side Effects Including cholesterol ratio. Smoking, diabetes, high blood pressure, abdominal obesity, psychological and emotional factors, and fruits /Vegetable intake, sports, and drinking
It estimates that by 2020. Cardiovascular diseases will surpass infectious diseases. And become the most crucial factor causing. Human disability and death worldwide. The proportion will grow from 25% in the 1990s to 40% in 2020.
A systematic literature review and meta-analysis (including 22 studies) pointed out that the use of CBD has no significant effect on blood pressure and heart rate improvement under control. Still, under stress, it has the effect of lowering blood pressure and heart rate. , And found to increase cerebral blood flow in the animal reperfusion injury (Ischemia-reperfusion injury) model.
Conclusion: It has been found in animal models that Cannabidiol may have a positive effect on cardiovascular function, but relevant human evidence is still insufficient and needs to be verified
Are there any side effects of CBD/ cannabidiol?
The currently limited studies have found that cannabidiol (Cannabidiol/CBD) is a potentially safe (POSSIBLY SAFE) substance for humans. No intolerance or toxicity has been found when used at an appropriate dose, but side effects or adverse effects have been reported. CBD oil for dogs Reactions include fatigue, diarrhea, dry mouth, hypotension, mild headache, dizziness, drowsiness, appetite changes, anxiety, irritability, weight change, respiratory infections… etc.
Safety precautions (use taboo at 8 points)
- Do not use for pregnant women, breastfeeding women, and children under two years old (because the relevant safety is unknown)
- For those with poor liver and kidney function. Please consult a medical professional before use (because the relevant safety is unknown)
- Do not use drugs because they may inhibit the liver enzymes related to metabolizing drugs (cytochrome P450. Which is responsible for the metabolism of more than 60% of prescription drugs). Thereby affecting the effects of drugs. And causing unknown risks.
- High-dose use may worsen the tremor and muscle movement symptoms of Parkinson’s disease patients.
- Please don’t use it for patients with low immune function (such as AIDS, diabetes, and Down syndrome) or take immunosuppressive agents because CBD (cannabidiol) may suppress immune function and increase infection risk.
- High doses of CBD may cause anxiety and irritability
- In several trials. It found that the combined use of CBD oil and anti-epileptic drugs. Valproate may cause liver damage. And the risk increases with increasing doses. And valproate, a drug known to cause liver damage.
- Do not use for patients with low blood pressure or taking. Blood pressure-lowering drugs. Which may lead to hypotension. (because CBD may have a blood pressure-lowering effect)